Crippling both will prevent any ability to attack. In such situations the areas to target would be:
In a defensive situation, it may be worth it to try to disarm or disable the enemy. Groin - Less critical hit potential and damage than head shots: but can sometimes ignore armor and often knock down/out targets.Head - Has a bit less critical hit potential and damage than eye shots: but still often ignores armor and can knock targets out.Eyes - Has the highest critical hit potential: highest damage multiplier, often ignores armor and can blind, reducing opponent's accuracy.In a first-strike situation, it is usually best to strike the deadliest blow possible: Different tactical situations may call for different aimed shots: Usually it is best to target areas with the most associated aiming penalty but still have high to-hit chance (90-95%) - this nets the highest possible critical chance, while not compromising on the accuracy.